I'm running PD Vanilla on an M1 Mac and no matter how simple the patch is, I can hear occasional glitch/skip/pop sounds in the audio. It sounds the same with any audio device I've tried, including built in speakers. Any idea what might cause this?

@adtubu Very hard to tell.... it could be a mismatch of sample rate between Pd and OSX......but if changing that does not solve the problem then try increasing the "delay msecs" setting in the Pd audio settings...... and finally if you are using Ventura then have a look at this thread.........
https://forum.pdpatchrepo.info/topic/14190/pd-crashing-on-mac
It is possible that @Riccardo-V managed to solve the similar problem.
David.